Monoclonal antibody target engagement is controllable with the presence or absence of small molecule KRasG12C inhibitors 

Hap10 technologies offer the promise of treating resistance to covalent inhibitors of oncoproteins

From the UCSF Laboratories of Charles Craik, Kevan Shokat and Mike Evans, with Ziyang Zhang and Peter Rohweder 

(click pictures for bios and publications)